Skip to content Polynucleotide injection side effects are not very common but these are important to discuss before getting this treatment.
Polynucleotide injections are a type of skin treatment that uses DNA from fish suspended in a gel to repair and rejuvenate the skin. They improve elasticity, deeply hydrate, and encourage collagen production in your skin. The result? Healthier and more youthful-looking skin.
Like any cosmetic treatment, however, polynucleotide injection has some side effects. For a smoother recovery, knowing the side effects and their management can be helpful.
This blog explores the various side effects of polynucleotide injection and how to manage them.
While polynucleotide injections are well-tolerated, some common and temporary side effects may resolve within 24-48 hours. They include:
Redness is common when you get polynucleotides under eyes. This is because the skin reacts to the injection process and its ingredients. The redness fades after a few hours or a day.
How to Cope Redness
A little swelling is expected and is part of the body’s healing process. It usually lasts one to two days.
How to Cope Swelling
Bruising can happen, especially when skin is thinner, such as under the eyes. This is because very small blood vessels can be damaged during the injection.
How to Cope with Bruising
You may experience some itching or tenderness at the injection site. This is usually due to your skin reacting to the treatment.
How to Deal with Itching or Tenderness
Now that you know the common side effects of polynucleotide injection treatment, let’s explore the rare ones.
Some side effects of polynucleotide injection side effects are very rare and may need the attention of your doctor immediately; they include:
Though rare, allergic reactions can be caused by the fish DNA used in polynucleotide injection. Symptoms include redness, swelling, and itching.
How to Manage Allergic Response
Though rare, infections can develop if improper hygiene is used during or after injections.
How to Manage Infection
Granulomas are small lumps that occur when the body views the injection material as foreign. These can occur weeks or even months after treatment.
How to Manage Granulomas
Vascular occlusion can occur with a polynucleotide injection if the needle accidentally blocks a blood vessel while injecting the treatment. This can prevent blood from flowing properly to the area. It may also happen if the injection is too deep or if the needle accidentally hits a small blood vessel.
How to Cope Vascular Occlusion
These practices can minimise the risk of side effects after polynucleotide treatment.
Always go to a certified and experienced doctor or aesthetic professional. Their expertise can greatly improve the treatment’s safety and success.
Don’t hesitate to ask your practitioner about their techniques, hygiene protocols, and what you can expect during recovery.
While preparing yourself for polynucleotide injections, follow these tips.
Skin care after polynucleotide injections is just as important as the treatment itself. Here are some top tips:
Polynucleotide treatment is an excellent revamp for refreshing the skin’s elasticity and hydration rate. The most common side effects of polynucleotide injections may appear to be a slight redness or some swelling. Still, they should resolve on their own with a smooth and stress-free healing recovery, considering what to know when they appear.
Following after-care tips and consulting a qualified practitioner can minimise risks while allowing you to reap the benefits of rejuvenating treatment. Remember, little preparation and care can go a long way toward achieving the glow of healthy skin!
Swelling, bruising, and tenderness are common side effects of polynucleotide injections, while rare risks may include allergic reactions and vascular occlusion.
Wrong placement or over-injection of the polynucleotides may cause this treatment to fail. However, getting it done by an expert reduces this risk.
In rare cases, the side effects of polynucleotide injections may stay longer, including persistent welling, allergy, and lumps.
The effects of polynucleotide injections generally last for 4 to 6 months. Age, lifestyle habits, and skin conditions are some factors that may influence this duration.
Please provide your details, and we will get back to you shortly.
Subcutaneous fat is the soft fat that sits just under your skin. Everyone has some of it, and a little is good because it protects your body and keeps you warm. But having too much can make you feel uncomfortable and can affect your health over time. Apart from appearing slimmer, losing subcutaneous fat helps […]
The causes of loose, flabby skin can include ageing, rapid or extreme weight loss, or other aspects such as sun damage or family traits. Flabby skin is usually not harmful, but it may just be a cosmetic concern. Fortunately, there are natural as well as professional ways through which one can improve flabby skin. For some […]
If you are looking to get Profhilo, there’s a question you must have asked yourself – how long does Profhilo last? If you are either a newbie or need a top-up, having an idea of what impacts the longevity of the treatment will help you make the most of it. In this blog, we’ll cover […]
When should you get a mole checked? If you notice a change in your mole’s size, shape, or colour, or if it becomes painful, itchy, bleeds, or looks different from your other moles, you should get it checked right away. Most moles are harmless, but changes can sometimes be an early sign of a skin […]
Sagging skin is a common concern that many people face as they age or experience lifestyle changes. It can affect anyone, regardless of gender, and often appears on the face, neck, arms, or body where the skin begins to lose its firmness. If you’ve noticed your skin looking less tight or your jawline less defined, […]
Explore Personalised Beauty Solutions
Please provide your details, and we will get back to you shortly.
Please provide your details, and we will get back to you shortly.
Consultant Plastic Surgeon
Dr. Mark Gorman is a consultant plastic surgeon and department lead at Salford Royal, specialising in facial plastics and complex reconstructive procedures. His expertise spans a wide range of areas, including oculoplastic, nasal, ear, abdominal, and microsurgical reconstruction, with particular focus on breast, head and neck, and lower limb reconstruction.
With a non-surgical and surgical skillet, Dr. Gorman is known for using advanced techniques to achieve natural, harmonious results. His approach often integrates dermal fillers and fat transfer to enhance facial features in combination with a range of deep plane facelifts.
Beyond facial aesthetics, his specialties include high-definition liposuction, allowing for precise body contouring.
Dr. Gorman’s approach to plastic surgery is rooted in skill, combining technical precision with a deep understanding of aesthetics to achieve refined and personalised outcomes for each patient.Dr.Gorman is a key opinion leader (KOL) for major UK aesthetic companies, also has taught at BAAPS (British Association of Aesthetic Plastic Surgeons), bringing his expertise to the next generation of surgeons.
Additionally, he runs his own aesthetic training company, further extending his influence in the field.Dedicated to total well-being, Dr. Gorman created the Look Body Mind philosophy, which blends aesthetics and wellness for a holistic approach to beauty.Whether you’re looking for subtle enhancements or comprehensive reconstructive work, Dr. Gorman’s patient-centered care, grounded in precision, skill and an exceptional aesthetic eye, ensures that you will feel confident throughout your journey.
Administrator
Sophie brings over a decade of customer service expertise to her role as Receptionist at Yorkshire Skin Centre. With a strong foundation in retail management and the travel industry, she is recognised for her warm, approachable manner and professional attitude—ensuring every client feels welcomed and valued from the moment they arrive.
Highly organised and calm under pressure, Sophie thrives in fast-paced environments and seamlessly manages a wide range of front-of-house responsibilities.
As the first point of contact for many clients, she plays a vital role in maintaining the clinic’s high standards of service and creating a smooth, reassuring experience for all visitors.
Beyond her professional skills, Sophie brings a vibrant energy to the team. She has a passion for travel, fashion, and music, and is currently learning both Spanish and Arabic. Her dedication to personal growth, combined with her friendly and proactive approach, makes her an indispensable part of our team.
Senior Surgical Sister(RN)
Herezel McCourt is a highly experienced Registered Nurse at Yorkshire Skin Centre, bringing over two decades of clinical expertise across diverse surgical and medical specialties. She holds a BSc (Hons) in Perioperative Practice from Huddersfield University, UK, and a BSc in Nursing from Cebu Doctors’ University in the Philippines.
Herezel has spent the majority of her career within the NHS, most recently as a Clinical Specialist in Ophthalmic Surgery at The MidYorkshire Teaching NHS Trust.
Her extensive background includes roles in operating theatres, anaesthetic care, ENT, urology, plastics, maxillofacial, orthopaedic, and podiatric nursing, among others.
Renowned for her professionalism, dedication, and compassionate care, Herezel is also a trained mentor, assessor, and ANTT trainer. She has led initiatives in recruitment, risk assessment, SOP development, and patient care pathway planning. Her leadership credentials are strengthened by a Level 3 Award in First Line Management and a strong commitment to staff development and peer support.
Herezel is a calm and supportive presence to both patients and colleagues, and her attention to clinical excellence makes her an invaluable member of the Yorkshire Skin Centre team.
Clinical Assistant
Rhea Levitt is a highly experienced Clinical Assistant at Yorkshire Skin Centre, known for her hands-on approach, warm personality, and commitment to delivering high-quality patient care. With a solid background in healthcare settings, Rhea brings valuable clinical expertise and administrative support to the team.
Her wide-ranging experience includes phlebotomy, wound care, ECGs, diabetic foot checks, B12 injections, and assisting in minor surgical procedures. She is also skilled in patient health monitoring, spirometry, and providing support during clinics such as coil fittings and cancer care.
Rhea’s well-rounded clinical knowledge is matched by her excellent organisational skills and a calm, compassionate approach to patient wellbeing.
In addition to her clinical duties, Rhea supports the practice by carrying out internal audits and ensuring best practices are upheld throughout the clinic. She plays a key role in maintaining smooth day-to-day operations and upholding the high standards that Yorkshire Skin Centre is known for.
Dedicated, professional, and always ready to help, Rhea is an invaluable member of the team who helps ensure that every patient receives attentive, safe, and seamless care.
Administrator
Raman holds a Bachelor of Science with Bachelor of Education (BSc, BEd) from India, a qualification that integrates scientific studies and teaching education, equipping her with a strong foundation in both fields. She is currently building her career in the UK healthcare industry, bringing her hardworking, compassionate, and friendly nature to the team.
With valuable experience in customer service and patient care, Raman plays a key role in managing day-to-day operations, handling bookings, and ensuring a smooth and welcoming experience for all patients.
Her dedication to excellence and passion for healthcare and client well-being make her an integral part of our team.
Practitioner
Nichola is a highly skilled practitioner with a strong background in beauty and holistic therapies. She earned her Level 3 Beauty Therapy qualification with distinction from the Yorkshire College of Beauty and further enhanced her expertise with Level 4 Specialist training. She is also CIDESCO-certified, an internationally recognized gold standard in beauty and spa therapy, ensuring clients receive the highest level of care and treatments.
With 18 years of customer service experience, primarily in the hospitality industry, Nichola deeply understands the importance of building strong client relationships. She is known for her hardworking nature, punctuality, and dedication to continuous learning.
Passionate about skincare and wellness, Nichola is committed to expanding her expertise in a leading skin clinic. She believes that the knowledge and experience she gains will be invaluable in delivering the highest standard of care to her clients.
“ Your journey to skin perfection starts here. Leave your details, and our expert team will be in touch shortly.”
Aesthetic Doctor
Expert Practitioner
Yorkshire Skin Centre in Leeds is a CQC registered medical clinic. Led by Dr Raj Thethi who completed his core surgical training in hospitals around West Yorkshire before branching into aesthetic medicine.
Dr Raj Thethi is a Northern Territory Regional Expert for an international dermal filler company called Teoxane. He also sits on their National UK Faculty. He is nationally recognised leader in the field of Aesthetics and a skilled trainer up..Yorkshire Skin Centre in Leeds is a CQC registered medical clinic. Led by Dr Raj Thethi who completed his core surgical training in hospitals around West Yorkshire before branching into aesthetic medicine.
Clinic Director
Patient Care Coordinator
Founder and Medical Director
Dr Raj is the Founder and Clinical Director of the Yorkshire Aesthetic Clinic. With a successful career in aesthetics and a passion for patient care, Dr. Raj found that his expertise in facial aesthetics was a natural progression where he could showcase his warm and friendly demeanour alongside his exceptional skills.
Dr Raj specialises in advanced facial aesthetics, offering a wide range of treatments and skin procedures. With his extensive training and experience in both medical and aesthetic fields, he brings a unique perspective to delivering exceptional results.
Driven by his passion for patient satisfaction, Dr Raj established the Yorkshire Aesthetic Clinic. Located in a comfortable and welcoming environment, the clinic provides a luxurious and refined setting for patients seeking aesthetic treatments…. Read More
Fill in the details below and download free eBook
Patient Representative
Hi, I’m Sarah Coates. I’m a Senior Change Manager, Hogan accredited coach, proud mum of 2 beautiful boys and am blessed with incredible friends to get into mischief with!
As I headed towards my 40th birthday, my life changed in a way that I could never have imagined and I came off that roller coaster with a new lease of life, with an understanding of the importance of self care and a huge amount of gratitude.
I love to travel, have a passion for interior design and enjoy sharing all that life has to offer with my beautiful family and fabulous friends.
If I’m not at work, you’ll find me playing at the park with my boys, enjoying the sun in Ibiza, listening to music or at the bar with a glass of fizz!
Patient Representative
Patient Representative
I am Senior Manager currently working for a small charity based in Leeds. My role is both professionally stimulating and challenging. No two days are ever the same. It includes aspects of advocacy, client rights, individual representation and inclusivity.
One milestone that resonates deeply is the creation of support groups, safe spaces where clients can openly share their stories. Witnessing the impact of these connections has fuelled my determination to improve the journey of others.
Through my own aesthetic endeavours , I’ve developed an unparalleled understanding of the emotional nuances tied to cosmetic treatments. This empathy allows me to offer sincere reassurance and guidance, especially during moments of vulnerability, in an era of aesthetic care that marries technical expertise with genuine human understanding and a person centred approach.
In my spare time I love the outdoors, enjoying hillwalking, taking part in sport, managing my bountiful allotment, and enhancing my cookery skills trying different cuisines (..no Masterchef yet).. and travel.
Consultant and General Surgeon
Dr. Khan earned her MD from Copenhagen University in 2003 and boasts over 20 years of medical expertise. Her early career was dedicated to dermatology and gynaecology across Yorkshire, and in 2011, she became a qualified GP from The Royal College of General Practitioners in London.
Dr. Khan’s commitment to women’s health is evident through her achievements. In 2012, she earned a Diploma in Sexual and Reproductive Health.
Sales Administrator
Excellent 470+ Reviews
on 
Independent Nurse Prescriber
Alana embarked on a career in nursing in 2008, following her comprehensive training and graduation. Since then, she has accrued a wealth of experience working in a variety of roles within both the NHS and private healthcare sectors. Known for her dedication and exceptional skills, Alana rapidly ascended into management, and for the past seven years, has been serving as a matron.
Throughout her career, she has consistently maintained her clinical competencies and academic studies. She initially earned a Bachelor’s degree in Nursing, later advancing her studies to become an Advanced Nurse Practitioner and Independent Prescriber. Her commitment to continuous professional development led to the completion of her full Master’s degree.
Alana’s passion for skin spurred her to further specialise in this field. In 2017, she pursued training in facial aesthetics, a decision that marked the beginning of a significant new chapter in her career. Since then, she has been affiliated with several leading skin clinics across the UK, where she has honed her expertise and built a reputation for excellence. Her extensive knowledge and experience in skin led her to become an expert medical trainer and since 2021, Alana has been imparting her knowledge at an award-winning training academy. Previously, she held the prestigious position of National Trainer for SKN Clinics, where she educated a variety of medical professionals, including plastic surgeons.
While Alana enjoys all aspects of skin, she has a particular fondness for medical-grade skin care, which she believes offers unparalleled benefits to patients. Her dedication to patient care and her professional knowledge and skills, make her a standout figure in this field. Through her work, Alana has positively impacted numerous lives, helping patients achieve their best skin health and aesthetic goals. In her trainer role, Alana is known for her meticulous approach and her ability to convey complex information in an accessible manner, ensuring that her trainees are well-equipped to deliver high-quality care. Her leadership and mentorship have been crucial in elevating the standards of practice within the industry.
Alana’s career is a testament to her unwavering commitment to excellence in nursing and aesthetics. Her professional journey reflects a blend of clinical expertise, academic achievement, and a genuine passion for improving patient care. As she continues to advance her career, Alana remains dedicated to staying at the forefront of the field, continually enhancing her skills and knowledge to provide the best possible care to her patients and to train the next generation of skin care professionals.
Consultant Plastic & Reconstructive Surgeon
With over 15 years of experience in the NHS, Mr Nikos Lymperopoulos specialises in reconstructive and cosmetic plastic surgery. He graduated from the University of Athens Medical in 2009 and completed his basic surgical training in Liverpool. After earning a PhD with honours in DIEP clinical anatomy research in 2013, he completed advanced surgical training in plastic surgery across Yorkshire and Liverpool, including a cosmetic fellowship in the North West.
Mr Lymperopoulos further honed his expertise with two prestigious breast reconstruction microsurgical fellowships at The Royal Marsden Hospital in Chelsea and Guy’s & St Thomas’ Hospitals in London. His extensive experience in breast reconstruction after mastectomy provides a profound understanding of surgical anatomy and aesthetics, benefiting procedures such as breast augmentation, reduction, and uplift. Additionally, he is highly skilled in abdominoplasty, often enhanced with liposuction or muscle repair, especially post-pregnancy.
Specialising in skin cancer treatment, he adeptly handles Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma. He offers a comprehensive range of breast and body cosmetic surgeries, including breast augmentation with implants or fat transfer, breast reduction, uplift, tummy tucks, and liposuction. Combined procedures, such as “mommy makeovers,” are also available to restore post-pregnancy body contours.
Trained in both surgical and non-surgical facial rejuvenation, Mr Lymperopoulos performs eyelid surgery (blepharoplasty), as well as toxin and filler injections. Currently, he serves as a Consultant at Mid Yorkshire Teaching Hospitals, specialising in breast reconstruction and skin cancer surgery, and holds an Honorary Senior Lecturer position at the University of Leeds.
An advocate for education and research, Mr Lymperopoulos has over 20 publications in peer-reviewed journals and a PhD in microsurgical breast reconstruction. As an Education Lead, he developed “The Yorkshire FRCS (Plast) Course” to aid UK trainees in their exit exams. His innovative training simulator was awarded first place in Innovation at the BAPRAS meeting in 2021.
Blepharoplasty, also known as an eye lift, is a surgical procedure performed on the eyelids to improve their appearance. It can address concerns like:
Excess skin on the upper eyelids: This can obstruct vision and create a hooded appearance.
Bags under the lower eyelids: These can make you look tired or aged.
Drooping lower eyelids: This can also obstruct vision and contribute to a tired appearance.
Types of Blepharoplasty:
Upper blepharoplasty: This addresses concerns with the upper eyelids, removing excess skin and sometimes fat or muscle tissue.
Lower blepharoplasty: This addresses concerns with the lower eyelids, removing excess fat or skin and sometimes repositioning tissues.
Asian blepharoplasty: This addresses specific concerns related to the anatomy of Asian eyelids, creating a more defined crease.
Consultant Ophthalmologist & Oculoplastic Surgeon
Mr Jeeva is celebrated for his mastery in aesthetic eyelid surgery. By adopting a patient-centric ethos, he delivers personalised treatments that amplify natural beauty and revive youthful vitality.
He has completed a prestigious fellowship at the Royal College of Surgeons, specialising in cosmetic plastic surgery. This rigorous training has endowed him with advanced techniques in aesthetic surgery, ensuring outcomes that are both beautiful and natural.
With a specialised fellowship in oculoplastic surgery, Mr Jeeva has honed his skills in delicate eyelid surgeries, tear duct disorders… Read More
